The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity - Université du Littoral Côte d'Opale Accéder directement au contenu
Article Dans Une Revue Biochemical Journal Année : 1993

The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity

Résumé

The substrate specificity of the core-specific rat liver lysosomal alpha(1-6)-mannosidase was investigated using mannosylated oligosaccharides and glycoasparagines. Hydrolysis of Man(alpha 1-6) linkage hydrolysis was demonstrated to follow the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase. The results are discussed with respect to the nature of the carbohydrate materials stored in the tissues and excreted in the urine from patients suffering from aspartylglucosaminuria and fucosidosis.

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Dates et versions

hal-03697234 , version 1 (20-06-2022)

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Citer

Jean-Franois Haeuw, Thierry Grard, Catherine Alonso, Jean-Claude Michalski. The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity. Biochemical Journal, 1993, 297 (3), pp.463-466. ⟨10.1042/bj2970463⟩. ⟨hal-03697234⟩

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