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The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity

Abstract : The substrate specificity of the core-specific rat liver lysosomal alpha(1-6)-mannosidase was investigated using mannosylated oligosaccharides and glycoasparagines. Hydrolysis of Man(alpha 1-6) linkage hydrolysis was demonstrated to follow the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase. The results are discussed with respect to the nature of the carbohydrate materials stored in the tissues and excreted in the urine from patients suffering from aspartylglucosaminuria and fucosidosis.
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https://hal-ulco.archives-ouvertes.fr/hal-03697234
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Submitted on : Monday, June 20, 2022 - 9:15:23 AM
Last modification on : Tuesday, June 21, 2022 - 3:06:13 AM

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Jean-Franois Haeuw, Thierry Grard, Catherine Alonso, Jean-Claude Michalski. The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity. Biochemical Journal, Portland Press, 1993, 297 (3), pp.463-466. ⟨10.1042/bj2970463⟩. ⟨hal-03697234⟩

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